Culture refers to the symbolic and learned aspects of human groups or societies, including language, beliefs, attitudes, values, norms, and behaviors. Immigrants who move to the United States (US) from other countries use different strategies to adapt to US culture, which is oftentimes quite different from the culture in which they grew up. We found that some South Asian immigrants in the MASALA study prefer to combine aspects of US and South Asian cultures, while others show a strong preference for either US or South Asian culture. We refer to these ways of adapting to life in the US as “acculturation strategies.” While there is no right or wrong way to adapt to life in a new country, we wanted to know whether people who use different acculturation strategies have different levels of depressive symptoms. Depression, which is characterized by feelings of sadness and hopelessness and problems with sleeping and eating, is a common mental health problem that is not always recognized or adequately treated by health care providers. After accounting for some important factors that might cause people to use different acculturation strategies and to have different levels of depressive symptoms, we found that immigrants in the MASALA study who showed a strong preference for South Asian culture had more symptoms of depression than those who showed either a preference for combining South Asian and US cultures or a strong preference for US culture. Future studies can help us understand why this is the case. If you or someone you know may be struggling with depression, you should know that effective treatments, including medications and talk therapy, are available. You can learn more about depression–and how to get help–on this website from the National Institutes of Health: https://www.nimh.nih.gov/health/publications/depression/index.shtml.